Kalen Josifovski


Navigating the frontier of chemistry, AI, and drug discovery—where data meets molecular innovation.
  • On pain & PROTACs

    A novel strategy for analgesia

    By Kalen Josifovski
    I first came across this paper after seeing a post on Pen’s excellent blog, Is life worth living?. The study explores a fresh approach using Proteolysis-Targeting Chimeras (PROTACs) to target voltage‐gated sodium channels (VGSCs) for the management of chronic pain—a condition that afflicts millions worldwide and has long been the... [Read More]